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Centre for Suicide Research | Research | Lithium review |
Systematic review of the efficacy of lithium therapy in affective disorders and in the prevention of suicide
We have carried out a systematic review of randomised controlled trials involving lithium in order to assess the evidence regarding the efficacy of lithium in the prevention of suicide and DSH. We are currently updating this review. The protocol was revised in October 2011. Download pdf of updated protocol.
We have also conducted a review of the general efficacy of lithium in the prophylaxis of mood disorders with Dr. Sally Burgess, Dr. Andrea Cipriani, Heather Wilder, Professor John Geddes, Professor Guy Goodwin and Professor Kay Jamison under the auspices of the Depression, Anxiety and Neurosis Review Group of the Cochrane Collaboration.
Publications:
Cipriani, A., Pretty, H., Hawton, K., Geddes, J. (2005) Lithium in the prevention of suicidal behaviour and all-cause mortality in patients with mood disorders: a systematic review of randomised trials. American Journal of Psychiatry, 162, 1805-1819
Geddes, J., Burgess, S., Hawton, K., Jamison, K., Goodwin, G. M. (2004) Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. American Journal of Psychiatry, 161, 217-222
Burgess S, Geddes J, Hawton K, Townsend E, Jamison K, Goodwin G. Lithium for maintenance treatment of mood disorders (Cochrane Review). In: The Cochrane Library, Issue 3, 2003. Oxford: Update Software.
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