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Dr Matthew Taylor
  • Clinical Lecturer and Hon. Specialist Registrar in Psychiatry
Contact
Interests
  • Efficacy and mechanisms of treatments for mood disorders.
  • Pathophysiology of mood disorders.
  • Antidepressant-associated sexual dysfunction.
Techniques
  • Neuroimaging.
  • Systematic reviews and meta-analysis.
Current Research Projects
  • Neurochemical effects of antidepressants.
  • Systematic reviews.
Publications
  • Howard MR, Taylor PRA, Lucraft HH, Taylor MJ, Proctor SJ. Bone Marrow Examination in newly diagnosed Hodgkin's disease: current practice in the United Kingdom. British Journal of Cancer 1995;71:210-212. PMID: 7819042 PubMed
  • Taylor MJ, Roberts DC, Zee DS. Effect of sustained cyclovergence on eye alignment: rapid torsional phoria adaptation. Investigative Ophthalmology and Visual Science 2000;41:1076-83. PMID: 10752944 PubMed [Full text here]
  • Taylor M, Bhagwagar Z, Cowen PJ, Sharp T. GABA and mood disorders. Psychological Medicine 2003;33:387-393. PMID: 12701660 PubMed
  • Harmer CJ, Hill S, Taylor MJ, Cowen PJ, Goodwin GM. Towards a neuropsychological theory of antidepressant drug action: Increase in positive emotional bias after potentiation of norepinephine activity. American Journal of Psychiatry 2003;160:990-992. PMID: 12727705 PubMed
  • Hill SA, Taylor MJ, Harmer CJ, Cowen PJ. Acute reboxetine administration increases plasma and salivary cortisol. Journal of Psychopharmacology 2003;17:273-275. PMID: 14513918 PubMed [Full text here]
  • Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews PM, Cowen PJ. Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor. American Journal of Psychiatry 2004;161:368-370. PMID: 14754790 PubMed [Full text here]
  • Taylor MJ, Carney SM, Goodwin GM, Geddes JR. Folate for depressive disorders: systematic review and meta-analysis of randomised controlled trials. Journal of Psychopharmacology 2004:18:251-256. PMID: 15260915 PubMed [DOI:10.1177/0269881104042630] ORA
  • Bhagwagar Z, Hinz R, Taylor M, Fancy S, Cowen PJ, Grasby PM. Increased 5-HT2A receptor binding in euthymic, medication free recovered depressed patients: a positron emission study with [11C]MDL100907. American Journal of Psychiatry 2006;163:1580-1587. PMID: 16946184 PubMed [Full text here]
  • Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z. Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Archives of General Psychiatry 2006;63:1217-1223. PMID: 17088502 PubMed [Full text here]
  • Taylor MJ, Carpenter RHS, Anderson AJ. A noisy transform predicts saccadic and manual reaction times to changes in contrast. Journal of Physiology 2006;573:741-751. PMID: 1779743 PubMed [Full text here]
  • Taylor MJ, Murphy S, Selvaraj S, Cowen P, Evans J. Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy. Journal of Psychopharmacology. In Press.xxxxxx
  • Bhagwagar Z, Murthy N, Selvaraj S, Hinz R, Taylor M, Fancy S, Grasby P, Cowen P. (2007) 5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study with [11C]DASB. American Journal of Psychiatry 2007 Dec;164(12):1858-65. PMID: 18056241 PubMed [Full text here]
  • Taylor M, Murphy SE, Selvaraj S, Wylezinska M, Jezzard P, Cowen PJ, Evans J. Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy. Journal of Psychopharmacology 2008;22:473-476. PMID: 18208909 PubMed
  • Hinz R, Selvaraj S, Murthy V, Bhagwagar Z, Taylor M, Cowen P, Grasby P. Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls. Journal of Cerebral Blood Flow and Metabolism 2008;28:1478-1490.
    PMID: 18478022 PubMed [Full text here]
  • Preece M, Taylor MJ, Raley J, Blamire A, Sharp T, Sibson NR. Evidence that increased 5-HT release evokes region-specific effects on blood-oxygenation level-dependent functional magnetic resonance imaging responses in the rat brain. Neuroscience 2009;159:751-9. PMID: 19174180 PubMed [doi:10.1016/j.neuroscience.2008.12.032]
  • Taylor MJ, Selvaraj S, Norbury R, Jezzard P, Cowen PJ. Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients. Journal of Affective Disorders 2009;119:186-189. PMID: 19324421 PubMed [doi:10.1016/j.jad.2009.02.022]
  • Norbury R, Taylor MJ, Selvaraj S, Murphy SE, Harmer C, Cowen PJ. Short-term antidepressant treatment modulates amygdala response to happy faces. Psychopharmacology 2009;206:197-204. PMID: 19585106 PubMed [doi:10.1007/s00213-009-1597-1]
  • Norbury R, Selvaraj S, Taylor MJ, Harmer C, Cowen PJ. Increased neural response to fear in patients recovered from depression: a 3T fMRI study. Psychological Medicine 2010;40:425-432. PMID: 19627640 PubMed [doi:10.1017/S0033291709990596]
  • Taylor MJ, Norbury R, Murphy S, Rudebeck S, Jezzard P, Cowen PJ. Lack of effect of citalopram on magnetic resonance spectroscopy measures of glutamate and glutamine in frontal cortex of healthy volunteers. Journal of Psychopharmacology 2010;24:1217-21.PMID: 19423614 PubMed [doi:10.1177/0269881109105679]
  • Taylor MJ, Mannie ZN, Norbury R, Near J, Cowen PJ. Elevated cortical glutamate in young people at increased familial risk of depression. International Journal of Neuropsychopharmacology In Press.
  • Taylor MJ, Sen S, Bhagwagar Z. Antidepressant response and the serotonin transporter gene-linked polymorphic region. Biological Psychiatry 2010;68:536-543.
    PMID: 20615496 PubMed [doi:10.1016/j.biopsych.2010.04.034]

Cochrane Reviews & Protocols

  • Taylor MJ, Carney S, Geddes J, Goodwin G. Folate for depressive disorders. The Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.: CD003390 Wiley
  • Taylor MJ, Wilder H, Bhagwagar Z, Geddes J. Inositol for depressive disorders. The Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD004049.pub2 Wiley
  • Rudkin L, Taylor MJ, Hawton K. Strategies for managing sexual dysfunction induced by antidepressant medication. The Cochrane Database of Systematic Reviews 2004 Issue 4. Art. No.: CD003382.pub2 Wiley
  • Brown RN, Taylor MJ, Wilder H, Geddes J. [Protocol] Aripiprazole alone or in combination for acute mania (Protocol). The Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD005000 Wiley

Some other studies

  • Taylor MJ, Geddes J. Folate also improves mental health (letter). BMJ 2004;320:768-769.
  • Taylor MJ, Rudkin L, Hawton K. Strategies for managing antidepressant-induced sexual dysfunction: systematic review of randomised controlled trials. Journal of Affective Disorders 2005;88:241-254.
  • Taylor MJ. Strategies for managing antidepressant-induced sexual dysfunction: a review. Current Psychiatry Reports 2006;8:431-436.
  • Taylor MJ, Goodwin GM. Long-term prophylaxis in bipolar disorder. CNS Drugs 2006;20:303-310.
  • Taylor MJ. Rapid onset of true antidepressant action. Current Psychiatry Reports 2007 Dec;9(6):475-9.