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John Geddes, M.D.

Current Appointments

  • Senior Clinical Research Fellow and Professor of Epidemiological Psychiatry, University of Oxford.
  • Honorary Consultant Psychiatrist, Oxford Mental Healthcare NHS Trust.
Contact
Trial Monitoring
  • Chair, Data Monitoring and Ethics Committee, START (RCT of psychological care in patients with cancer PI: Professor Michael Sharpe)
  • Chair, Data Monitoring and Ethics Committee, CutLASS (RCT comparing atypical and conventional antipsychotics in schizophrenia; PI: Professor Shon Lewis)
  • Member, Data Monitoring and Ethics Committee, DART-AD, Member, Trial Steering Committee of PRP
  • Member, Trial Steering Committee of MRC-funded GenPod trial
Committees
  • 2009 Member, Office for Strategic Co-ordination of Health Research Review of Mental Health Research Strategic Review Group
  • 2008 Member, Medical Research Council Strategic Review of Neurodegeneration
  • 2000-2010 Medical Research Council Advisory Board and College of Experts
  • 2008 -  Medical Research Council Population Health Sciences Group
  • 2006-2008 Medical Research Council Health Services and Public Health Research Board
  • 2008-present Medical Research Council Neurosciences and Mental Health Board
  • 2003-continuing   Appraisals Committee, National Institute for Health and Clinical     Excellence (NICE) 
  • Professional Grant Review Panel, Stanley Medical Research Institute, Washington DC
Awards
  • Elected Honorary Fellow of American College of Psychiatrists for outstanding contribution to the field of psychiatry – March 2008
  • NHS Health and Social Care Award – Mental Wellbeing category. South Central regional award (with OCTUMI) – April 2008
  • NHS Health and Social Care Award – NHS Live category, National award - July 2008
  • Royal College of Psychiatrists academic psychiatrist of year nominee - 2010
Publications

Books

  • Harrison PJ, Geddes JR and Sharpe M. Lecture Notes in Psychiatry. 8th Edition. Blackwells 1998 [see below for link to 9th ed.]
  • Gelder MG, Mayou RA, Geddes JR. Concise Oxford Textbook of Psychiatry. 2nd Edition. OUP 1999 [see below for link to 3rd ed.]
  • Geddes JR, Tomlin A and Price J. Practising evidence-based mental health. Radcliffe Medical Press, Oxford 1999 External Link
  • National Schizophrenia Guideline Group. The Management of Schizophrenia Part 1. Pharmacological treatments. Gaskell. London 2001 External Link
  • Harrison PJ, Geddes JR and Sharpe M. Lecture Notes in Psychiatry. 9th Edition. Blackwells 2005 External Link
  • Gelder MG, Andreasen N, Ibor-Lopez J, Geddes JR (Eds). New Oxford Textbook of Psychiatry, 2 edition OUP 2009
  • Harrison PJ, Geddes JR and Sharpe M.  Lecture Notes in Psychiatry 10th edition Wiley-Blackwell 2010
  • Gelder MG, Mayou RA, Geddes JR. Psychiatry - An Oxford Core Text (formerly the Concise Oxford Textbook of Psychiatry). 4th Edition. OUP 2011 External Link

Chapters

  • Geddes JR. Debate in Dawson A and Tylee A (eds) Depression: Social and economic timebomb. BMJ Books, London, 2000 External Link
  • Geddes JR. From science to practice in Gelder MG and Andreason NC (Eds) New Oxford Textbook of Psychiatry. OUP 2001 External Link
  • Geddes JR. Evidence-based practice in mental health in Reynolds S and Trinder L (Eds) Evidence-based practice. Blackwells 2000 External Link
  • Geddes JR. Systematic reviews in Brown B and Wilkinson G (Eds) Critical Reviews in Psychiatry Gaskell, London 1999 External Link
  • Lawrie SM and Geddes JR. Evidence-based psychiatry in Johnstone EC, Freeman CP and Zealley AK (Eds). Companion to Psychiatric Studies 6th Edition Churchill Livingstone, 1999 External Link
  • Geddes JR and Butler R. Depressive disorders in Clinical Evidence BMJ Publishing Group, London, 2002 External Link
  • Carney SM and Geddes JR. Systematic Reviews and Meta-analyses in Evidence in Mental Health Care Eds Priebe S and Slade M Brunner Routledge, Hove 2002 External Link
  • Geddes JR. Bipolar disorders in Clinical Evidence BMJ Publishing Group, 2004 External Link
  • Butler R, Carney S, Cipiriani A, Geddes J, Hatcher S, Price J, Von Korff M. Depressive disorders in Clinical Evidence BMJ Publishing Group, London, 2004 External Link
  • Geddes JR. Evidence-based practice in Worrall A and Kendal T (Eds) Clinical Governance in Mental Health and Learning Disability Services, Gaskell, London, 2005 External Link
  • Cipriani A, Bargui C, Baethge C, Wilder H, Geddes J. Antidepressive Monotherapie in Bauer M, Berghofer A, Adli M (Eds). Akute und therapieresistente Depressionen: Pharmakotherapie, Psychotherapie, Innovationen Springer Medizin Verlag, Heidelberg, 2005 External Link
  • Coryell W and Geddes JR.  Psychopharmacology of mood disorders in Tyrer P, Silk K (eds) Cambridge Textbook of Effective Treatments in Psychiatry Cambridge University Press 2008 External Link
  • Temple S and Geddes JR.  Psychotherapy for depression: current empirical status and future directions in Tyrer P, Silk K (eds) Cambridge Textbook of Effective Treatments in Psychiatry Cambridge University Press 2008 External Link
  • Geddes JR.  Number Needed to Treat in Towl GJ, Farrington DP, Crighton DA, Hughes G (eds) Dictionary of Forensic Psychology Willan Publishing 2008

Papers

  • Turkington D, Geddes J. (1990): Delusional Depression in Binswanger's Disease Responding to Clomipramine A Case Report. Journal of Nervous and Mental Disease 178:459-460 PMID: 2366061 PubMed
  • Geddes JR, Huws R and Pratt P (1991): Olfactory Acuity in the Positive and Negative Syndromes of Schizophrenia. Biological Psychiatry 29:774-778 PMID: 2054451 PubMed
  • Macaskill, N.D., Geddes, J.R., Macaskill, A. (1991): DSM-III in the UK: A national survey. International Journal of Social Psychiatry 37 182-186 PMID: 1743902 PubMed
  • Newton R and Geddes J (1992): Resettlement of long-stay patients in the community. Psychiatric Bulletin 16, 370-371 External Link
  • Geddes, J.R. Reynolds G.A., Rattenbury, J. Peet, M (1992): The ratio of phenylalanine to other LNAA is not a risk factor for tardive dyskinesia. Journal of Psychopharmacology 6: 278-280 External Link
  • Geddes J.R., Black R.J., Whalley, L.J., Eagles, J.M. (1993). Persistence of the decline in the diagnosis of schizophrenia among first admissions to Scottish hospitals from 1969-1988. British Journal of Psychiatry. 163: 620-626 PMID: 8298830 PubMed
  • Rowlands, P & Geddes, J.R (1993): Journal Clubs Psychiatric Bulletin 17, 363-364
  • Johnstone E.C. & Geddes J.R. How high is the relapse rate in schizophrenia? (1994): Acta Psychiatrica Scandinavica 89 (suppl 382): 6-10 PMID: 7916528 PubMed
  • Geddes J.R., Newton J.R., Bailey S., Young G., Freeman C.P., Priest R.G. (1994): Comparison of the prevalence of schizophrenia among the residents of hostels for the homeless in 1966 and 1992. British Medical Journal 308: 816-819 PMID: 8167488 PubMed
  • Newton J.R., Geddes J.R., Bailey S., Freeman C.P, Young G. (1994) A survey of the mental health of the Edinburgh "roofless" British Journal of Psychiatry. 165: 537-540 PMID: 7804671 PubMed
  • Humphreys M & Geddes J.R. (1994) Mental Health Law. British Medical Journal 308: 857 PMID: 8167506 PubMed
  • Geddes, J.R. & Lawrie, S.M. (1994) Dualism in psychiatry. Lancet 343 1102 PMID: 7909121 PubMed
  • Geddes J.R., Newton J.R., Bailey S., Young G., Freeman C.P., Priest R.G. (1994): Schizophrenia among the residents of hostels for the homeless. British Medical Journal 308: 816-819PMID: 8080578 PubMed
  • Geddes J.R., Black R.J., Whalley, L.J., Eagles, J.M. (1993) Decline in the diagnosis of schizophrenia. British Journal of Psychiatry 164 PMID: 8298830 PubMed
  • Geddes J.R. Mercer G, Frith, C.D., Macmillan J.F., Owens, D.G.C.O., Johnstone, E.C. (1994) The prediction of outcome following first schizophrenic episode: a follow-up study of Northwick Park First Episode Study subjects. British Journal of Psychiatry 165: 664-669 PMID: 7866682 PubMed
  • Eagles, J.M. Hunter D, Geddes, J.R. (1995) Gender specific changes since 1900 in the schizophrenic season of birth effect. British Journal of Psychiatry 167: 469-473 PMID: 8829714 PubMed
  • Geddes, J.R. & Kendell R.E. (1995) Schizophrenic subjects with no history of admission to psychiatric hospital. Psychological Medicine 25: 859-868 PMID: 7480464 PubMed
  • Geddes JR & Lawrie SM (1995) Obstetric complications and schizophrenia: a meta-analysis. British Journal of Psychiatry 167 786-793 PMID: 8829748 PubMed
  • Geddes JR & Juszczak E.(1995) Period trends in the rate of suicide in the first 28 days after discharge from psychiatric hospital in Scotland, 1968-1992. British Medical Journal 311:357-60 PMID: 7640540 PubMed
  • Harrison PJ & Geddes JR (1995) Of molecules, mice and meta-analyses. 1995 Psychiatry review. Lancet 346 (suppl) s19 PMID: 9454036 PubMed
  • Morrison R & Geddes, J.R. (1996) Working for the Mental Welfare Commission for Scotland - report of a senior registrar attachment. Psychiatric Bulletin 20:480-481 External Link
  • Geddes, J.R. Newton, J.R., Young, G., and Bailey, S. (1996) Prevalence of psychiatric disorder, cognitive impairment and functional disability among homeless people resident in hostels. Health Bulletin; 54: 276-279 PMID: 8707573 PubMed
  • Geddes JR, Christofi G, Sackett DL (1996) Commentary on "First-rank symptoms or rank-and-file symptoms". British Journal of Psychiatry 169:544-545
  • Taylor J, Lawrie SM, Geddes JR. (1996) Factors associated with admission to hospital following emergency assessment. Health Bulletin 54(6): 467-473 PMID: 8990612 PubMed
  • Beer S & Geddes J (1996) Schizophrenia. General Practitioner November 1 41-44
  • Geddes JR (1996) On the need for evidence-based psychiatry. Evidence-Based Medicine 1: 199-200 External Link
  • Geddes JR, Game D, Jenkins NE, Peterson LA, Pottinger GR and Sackett DL. What proportion of primary psychiatric interventions are based on randomised evidence? Quality in Health Care 1996 5:215-217 PMID: 10164145 PubMed
  • Lawrie, S.M., Manders, D.N., Geddes, J.R., and Pelosi, A.J. A population-based incidence study of chronic fatigue. Psychological Medicine 27:343-353, 1997. PMID: 9089827 PubMed
  • Geddes JR Using evidence about clinical effectiveness in everyday clinical practice. Psychiatric Bulletin 21: 390-393, 1997 External Link
  • Geddes, J.R., Juszczak, E., O'Brien, F., and Kendrick, S. Suicide in the 12 months after discharge from psychiatric inpatient care, Scotland 1968-92. Journal of Epidemiology & Community Health 51:430-434, 1997. PMID: 9328552 PubMed
  • Geddes JR Evidence-based medicine and psychiatry. Irish Journal of Psychological Medicine 14; 83-84 1997 External Link
  • Verdoux H, Geddes JR Takei N, Lawrie SM, P Bovet, JM Eagles, R Heun, RG McCreadie, TF McNeil, E O'Callaghan, G Stober, U Willinger Murray RM Obstetric complications and age of onset in schizophrenia: an international collaborative meta-analysis of individual patient data. American Journal of Psychiatry 154; 1220-1227 1997 PMID: 9286180 PubMed
  • Geddes JR and Harrison PJ Evidence-based psychiatry: closing the gap between research and practice. British Journal of Psychiatry 171, 220-225 1997 PMID: 9337970 PubMed
  • Geddes JR, Verdoux H, Takei N, Lawrie SM, P Bovet, JM Eagles, R Heun, RG McCreadie, TF McNeil, E O'Callaghan, G Stober, U Willinger, Murray RM. Individual patient data meta-analysis of the association between schizophrenia and specific abnormalities of pregnancy and labour. Schizophrenia Bulletin 25(3):413-423, 1999 PMID: 10478777 PubMed
  • Powell J & Geddes JR (1997) Evidence-based psychiatry. British Journal of Psychiatry 586-587 PMID: 9519112 PubMed
  • Geddes, J.R., Reynolds, S., Streiner, D., and Szatmari, P. Evidence based practice in mental Health. British Medical Journal 315:1483-1484, 1997. Invited editorial PMID: 9420484 PubMed
  • Sheehan B and Geddes JR (1998) Diogenes syndrome: review and case history. Irish Journal of Psychological Medicine 15(2): 76-79 External Link
  • Streiner DL and Geddes JR Some useful concepts and terms used in articles about diagnosis. Evidence Based Mental Health 1998 1: 6-7 External Link
  • Verdoux H, Geddes JR, Takei N, Murray RM. Association between age at onset of schizophrenia and obstetric complications. American Journal of Psychiatry 155:1644-1655, 1998.
  • Geddes J.R. Reynolds, S., Streiner, D., and Szatmari, P. Evidence based practice in mental health. Evidence Based Mental Health 1998 1; 4-5 External Link
  • Freemantle N, Geddes JR. Understanding and interpreting systematic reviews and meta-analyses. Part 2: meta-analyses. Evidence-Based Mental Health 1998;1:102-104. External Link
  • Geddes JR Modifications seculares de l'incidence de la sxhizophrenie. Halopsy 1999; 22:2-5
  • Geddes J. Asking structured and focused clinical questions: essential first step of evidence-based practice. Evidence-Based Mental Health 2(2):35-36, 1999. External Link
  • Geddes JR Prenatal and perinatal risk factors for early onset schizophrenia, affective psychosis, and reactive psychosis British Medical Journal 1999; 318; 426 PMID: 10084831 PubMed
  • Geddes JR Suicide and Homicide in mentally ill patients. British Medical Journal 1999 318: 1225-1226 PMID: 10231231 PubMed
  • Furukawa T, Geddes J (1999) Introduction to evidence-based psychiatry 1. Introduction. Rinsho Seishin-Igaku (Japanese Journal of Clinical Psychiatry), 28 (8): 1049-1054.
  • Geddes JR The contribution of information technology to improving clinicians' access to high quality evidence. International Journal of Psychiatry in Medicine 1999 29 (3) 287-292 PMID: 10642903 PubMed
  • Powell J, Geddes J, Deeks J, Hawton K, Goldacre M Suicide in psychiatric hospital inpatients: Risk factors and their predictive power. British Journal of Psychiatry 2000, 176; 266-27 PMID: 210755075 PubMed
  • Geddes J and Wessely S. Clinical standards in psychiatry. How much evidence is required and how good is the evidence base? Psychiatric Bulletin 24:83-84, 2000. External Link
  • Geddes J (2000) Introduction to evidence-based psychiatry 9. Using a clinical practice guideline. Rinsho Seishin-Igaku (Japanese Journal of Clinical Psychiatry), 29 (6): 685-690.
  • Geddes JR, Freemantle N, Harrison P, Bebbington PE, Atypical antipsychotics in the treatment of schizophrenia - systematic overview and meta-regression analysis. British Medical Journal 2000; 321: 1371-1376 PMID: 11099280 PubMed
  • Tomlin A, Dearness KL, Geddes J. Quality of health information about depression on internet. BMJ 322 (7298):1366-1367, 2001. PMID: 11409402 PubMed
  • Geddes JR and Goodwin GM Bipolar disorder: clinical uncertainty, evidence-based medicine and large-scale randomised trials. British Journal of Psychiatry 2001; 178 (suppl. 41): s191-s194 PMID: 11450182 PubMed
  • Geddes JR and Carney SM Recent advances in evidence-based psychiatry. Canadian Journal of Psychiatry 2001;46(5):403-6 PMID: 11441777 PubMed
  • Streiner DL, Geddes JR Intention to treat analysis when there are missing data. Evidence-Based Mental Health 4(3):, 2001 PMID: 12004740 PubMed
  • Geddes JR Prevention of relapse in schizophrenia. New England Journal of Medicine 346; 56-58; 2002 PMID: 11778005 PubMed
  • Geddes JR, Rendell JM, Goodwin GM. BALANCE: a large simple trial of maintenance treatment for bipolar disorder. World Psychiatry 1; 48-51; 2002 External Link
  • Barnard L, Young, AH, Pearson J, Geddes J, O'Brien G. A systematic review of the use of atypical antipsychotics in autism. Journal of Psychopharmacology 16(1); 93-101, 2002 PMID: 11949778 PubMed
  • Pilling, S., Bebbington, P., Kuipers, E., Garety, P., Geddes, J., Orbach, G. and Morgan, C. Psychological treatments in schizophrenia. I meta-analysis of family intervention and cognitive behaviour therapy. Psychological Medicine 2002, 32, 763-782 PMID: 12171372 PubMed
  • Pilling, S., Bebbington, P., Kuipers, E., Garety, P., Geddes, J., Martindale, B., Orbach, G. and Morgan, C. Psychological treatments in schizophrenia. II: meta-analyses of randomised controlled trial of social skills, training and cognitive remediation. Psychological Medicine 2002, 32, 783-791 PMID: 12171373 PubMed
  • Geddes, JR Mood stabilizers: clinical application of randomised evidence. Journal of Psychopharmacology 2002, 16 (suppl) A9 External Link
  • Geddes JR, Butler R Depressive Disorders American Family Physician 2002; 1395-1397 PMID: 11996424 PubMed
  • Geddes JR Can we conduct some large simple trials in bipolar disorder? Bipolar Disorder 2002: 4 (Suppl. 1): 62-63 PMID: 12479680 PubMed
  • Geddes JR, Goodwin GM, Rendell J, Hainsworth J, van der Gucht E, Young H New trial should clarify lithium use in bipolar disorder (letter). British Medical Journal 2002; 325: 441 PMID: 12193365 PubMed
  • Geddes JR, Freemantle N, Cipriani A. Low dose tricyclics: making the best use of the available evidence, 11 Dec 2002 External Link
  • Taylor M, Geddes J Current drug treatments available for psychosis. Prescriber 2002, 23. External Link
  • Geddes JR, Carney SM, Davies C, Furukawa TA, Kupfer DJ, Frank E, Goodwin GM Relapse prevention with antidepressant drug treatment in depressive disorders. Lancet 2003, 361: 653-61 PMID: 12606176 PubMed
  • Geddes JR: The UK ECT Review Group Electroconvulsive therapy - systematic review and meta-analysis of efficacy and safety in depressive disorders. Lancet 2003, 361: 799-808 PMID: 12642045 PubMed
  • Warren, F., McGauley, G., Norton, K., Preedy-Fayers, K.,Pickering, A. Geddes, J.R. and Dolan, B., 2003 Review of Treatments for severe personality disorder. Online Report 30/03. London: Home Office. External Link
  • Geddes J, Goodwin G, Carney S, Frank E, Kupfer D(letter) Lancet 2003, 361: 2159
  • Carney S, Geddes J Electroconvulsive therapy (editorial). British Medical Journal 2003, 326: 1343-4 PMID: 12816798 PubMed
  • Geddes JR Generating evidence to inform policy and practice - the example of the second generation "atypical" antipsychotics. Schizophrenia Bulletin 2003;29(1):105-14 PMID: 12908665 PubMed
  • Geddes J, Harrison P, Freemantle N New generation antipsychotics versus conventional antipsychotics (letter). Lancet 2003; 362(9381):404 PMID: 12907021 PubMed
  • Rendell JM, Geddes JR, Ostacher MJ. Older patients are eligible for trial of lithium and valproate. BMJ. 2003; 327(7411):395-6 PMID: 12920009 PubMed
  • Goodwin GM, Geddes JR Latest maintenance data on lithium in bipolar disorder. Eur Neuropsychopharmacol. 2003; Suppl 2:51-5. PMID: 12957720 PubMed
  • Harrison PJ, Freemantle N, Geddes JR Meta-analysis of brain weight in schizophrenia. Schizophrenia Research 2003; 64: 25-34 PMID: 14511798 PubMed
  • Cipriani A, Geddes JR Comparison of systematic and narrative reviews: the example of the atypical antipsychotics. Epidemiologia e Psichiatria Sociale 2003 146-153 PMID: 14610849 PubMed
  • Geddes JR Bipolar Disorder. Evidence-based Mental Health 2003 6 101-102 PMID: 14585776 PubMed
  • Geddes JR Prodromal symptoms may be identified by people with bipolar or unipolar depression. Evidence-Based Mental Heath 2003; 6: 105 PMID: 14585778 PubMed
  • Geddes J, Burgess S, Hawton K, Jamison K, Goodwin G. Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomised controlled trial. American Journal of Psychiatry 2004 217-222 PMID: 14754766 PubMed
  • Rendell JM, Juszczak E, Hainsworth J, Van der Gucht E, Healey C, Morriss R, Ferrier N, Young AH, Young H, Goodwin GM, Geddes JR. Developing the BALANCE trial - the role of the pilot study and start-up phase. Bipolar Disord 2004: 6: 26-31 External Link
  • Palumbo G, Morosini P, Picardi A, Gigantesco A, Geddes J Educating mental health professionals in clinical epidemiology and continuous quality improvement: usefulness of short, intensive courses. Administration and Policy in Mental Health 2004 May; 31(5): 421-4 PMID: 15379387 PubMed
  • Schmidt U, Block B, Cooper PJ, Essers MH, Freeman CPL, Holland RL, Palmer RL, Shur E, Russell GFR, Bowler C, Coker S, Geddes JR, Mackenzie F, Munro J, Newton R, Tiller J, Tattersall M, Vize C, Webster Fluvoxamine and graded psychotherapy in the treatment of bulimia nervosa. A randomised, double-blind, placebo-controlled, multi-centre study of short term and long term pharmacotherapy combined with a stepped care approach to psychotherapy. Journal of Clinical Pharmacology 2004 24 PMID: 15349014 PubMed
  • Taylor MJ, Carney SM, Goodwin GM, Geddes JR Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. Journal of Psychopharmacology (2004) 251-256 PMID: 15260915 PubMed
  • Goodwin GM, Geddes JR Introduction to systematic reviews. Journal of Psychopharmacology (2004) 249-250 PMID: 15260914 PubMed
  • Cipriani A, Geddes JR Commentary: analysis and reporting of factorial trials. Cochrane Collaboration Methods Groups Newsletter (2004) 8 20-21
  • Geddes JR Bipolar Disorder. American Family Physician (2004) 69 1715-1717 External Link
  • Geddes JR Managing depressive disorder: how can the GP best help? The New Generalist 2004 2 3 External Link
  • Gijsman HJ, Geddes JR, Rendell JM, Nolen WA, Goodwin GM Antidepressants for Bipolar Disorder: a systematic review of randomized controlled trials. American Journal of Psychiatry (2004) 161:1537-1547 PMID: 15337640 PubMed
  • Geddes JR, Szatmari P, Streiner D. The worm turns: publication bias and trial registers revisited. Evidence-Based Mental Health (2004) PMID: 15504788 PubMed
  • Geddes JR, Cipriani A Selective serotonin reuptake inhibitors. British Medical Journal (2004) PMID: 15472236 PubMed
  • Cipriani A, Barbui C, Geddes JR Suicide, depression, and antidepressants Patients and clinicians need to balance benefits and harms. British Medical Journal (2005) 330; 373-374 PMID: 15718515 PubMed
  • Cipriani A, Wilder H, Hawton K & Geddes JR. Lithium in the prevention of suicidal behaviour and all-cause mortality in patients with mood disorders: a systematic review of randomised trials. American Journal of Psychiatry 2005; 162:1805-1819 PMID: 16199826 PubMed
  • Geddes JR Large simple trials in psychiatry - providing reliable answers to important clinical questions. Epidemiologia e Psichiatria Sociale 2005 PMID: 16255157 PubMed
  • Wijkstra J, Lijmer J, Balk FJ, Geddes JR, Nolen WA Pharmacological treatment for unipolar psychotic depression. British Journal of Psychiatry PMID: 16648526 PubMed
  • Cipriani A, Barbui C, Brambilla P, Furukawa TA, Hotopf M, Geddes J Are all antidepressants really the same? The case of fluoxetine: a systematic review. Journal of Clinical Psychiatry PMID: 16848644 PubMed
  • Geddes JR Commentary: Bipolar Disorder - services need to catch up with rapidly developing evidence-base. British Medical Journal 2006; 332:32-33 PMID: 16399735 PubMed
  • Cipriani A, Barbui C, Brambilla P, Furukawa TA, Hotopf M, Geddes J. Are all antidepressants really the same? The case of fluoxetine: a systematic review.  Journal of Clinical Psychiatry  67(6): 850-864 PMID: 16848644 PubMed
  • Geddes JR.  Commentary: Bipolar Disorder – services need to catch up with rapidly developing evidence-base.  British Medical Journal 2006; 332:32-33 PMID: 1325131 PubMed
  • Geddes JR,  Lloyd S, Simpson A, Rossor M, Fox N, Hill D, Hajnal JV, Lawrie S, McIntosh A, Johnstone EC, Wardlaw J, Perry D, Procter R, Bath P, Bullmore E.  The Challenges of developing a collaborative data and compute grid for Neurosciences.  Proceedings - IEEE Symposium on Computer-Based Medical Systems 2006 art. no. 1647550: 81-86 External Link
  • Geddes JR. Meta-analysis in the assessment of treatment outcome.  Journal of Psychopharmacology 2006 20 (4) Supplement 67-71 PMID: 16785273 PubMed
  • Geddes JR,  Goodwin GM, Huffman R, Paska W, Evoniuk G, Leadbetter  R.  Additional clinical trial data and a retrospective pooled analysis of response rates across all randomised trials conducted by GSK.  Bipolar Disorders 2006 8(suppl 1): 32
  • Hockney RA, Montgomery P, Williams C, Geddes JR, Cowen P.  Lack of effect of chromium supplementation on mental state and body weight in people with schizophrenia. Journal of Clinical Psychopharmacology 26 (4): 1-2 2006 PMID: 16974208 PubMed
  • Geddes JR.  Providing the best available evidence.  Advances in Psychiatric Treatment 2006 12: 327-328 External Link
  • Geddes J , Mackay C, Lloyd S, Simpson A, Power D, Russell D, Jirotka M, Katzarova M, Rossor M, Fox N, Fletcher J, Hill D, McLeish K, Chen Y, Hajnal JV, Lawrie S, Job D, McIntosh A, Wardlaw J, Sandercock P, Palmer J, Perry D, Procter R, Ure J, Hartswood M, Slack R, Voss A, Ho K, Bath P, Clarke W, Watson G.  Designing for e-Health: recurring scenarios in developing grid-based medical imaging systems.  Studies in Health technology and Informatics 2006 120: 336-347 PMID: 16823151 PubMed
  • Geddes JR.  The European Directive on Clinical Trials: how to live with it and still do independent clinical trials (Abstract).  Journal of Psychopharmacology 2006 20 5 (suppl) S2 A
  • Taylor MJ, Freemantle N, Geddes JR, Bhagwagar Z.  Early onset of selective serotonin reuptake inhibitor antidepressant action - Systematic review and meta-analysis.  Archives of General Psychiatry  2006  63, 11: 1217-1223 PMID: 17088502 PubMed
  • Wijkstra J,  Lijmer J, Balk FJ, Geddes JR, Nolen WA.  Pharmacological treatment for unipolar psychotic depression – systematic review and meta-analysis.  British Journal of Psychiatry 188: 410-415 2006 PMID: 16648526 PubMed
  • Merritt RK, Price JR, Mollison J & Geddes JR.  A cluster randomized controlled trial to assess the effectiveness of an intervention to educate students about depression.  Psychological Medicine 2007 37: 363-372 PMID: 17311685 PubMed
  • Wardlaw, J. M. Bath P, Sandercock P, Perry D, Palmer J, Watson G, Lloyd, S, Geddes J and Farrall A.  The NeuroGrid stroke exemplar clinical trial protocol. International Journal of Stroke 2 (1): 63-69  2007 PubMed
  • Cipriani, A, Geddes JR, Barbui C. Venlafaxine for major depression.  British Medical Journal  2007 334: 215-216 PMID: 1790758 PubMed
  • Lloyd S, Simpson A, Power D, Geddes J, Khanbhan A, Palmer J.  Developing Collaborative Technology for Neuro-Science. External Link
  • K Soares-Weiser, Vergel Y Bravo, S Beynon,  G Dunn, M Barbieri,  S Duffy, J Geddes, S Gilbody, S Palmer and N Woolacott.  A systematic review and economic model of the clinical effectiveness and cost-effectiveness of interventions for preventing relapse in people with bipolar disorder. Health Technol.Assess. 11 (39): 1-226  2007 PMID: 17903393 PubMed
  • G.M. Goodwin and J.R. Geddes. What is the heartland of psychiatry?  Br.J.Psychiatry 191: 189-191 2007 PMID: 17766755 PubMed
  • John R Geddes, Toshi A Furukawa, Andrea Cipriani, Corrado Barbui.  Depressive Disorder Needs an Evidence Base Commensurate With Its Public Health Importance.  The Canadian Journal of Psychiatry 2007 52: 543-544 PMID: 17953157 PubMed
  • Toshi A Furukawa, Andrea Cipriani, Corrado Barbui, John R Geddes.  Long-Term Treatment of Depression With Antidepressants: A Systematic Narrative Review.  The Canadian Journal of Psychiatry 2007 52: 545-552 PMID: 17953158 PubMed
  • Andrea Cipriani, John R Geddes, Toshi A Furukawa, Corrado Barbui.  Metareview on Short-Term Effectiveness and Safety of Antidepressants for Depression: An Evidence-Based Approach to Inform Clinical Practice.  The Canadian Journal of Psychiatry 2007 52: 553-562 PMID: 17953159 PubMed
  • Beynon S, Soares-Weiser K, Woolacott N, Duffy S, Geddes JR. Psychosocial interventions for the prevention of relapse in bipolar disorder: systematic review of controlled trials. BritishJournal of Psychiatry 2008 192 (1):5-11 PMID: 18174500PubMed
  • Stroup TS; Geddes JR.  Randomized Controlled Trials for Schizophrenia: Study Designs Targeted to Distinct Goals Schizophrenia Bulletin 2008 34: 266-274 PMID: 18245060 PubMed
  • Miklowitz DM, Goodwin GM, Bauer MS, Geddes JR.  Common and Specific Elements of Psychosocial Treatments for Bipolar Disorder: A Survey of Clinicians Participating in Randomized Trials J Psychiatric Practice 2008 14(2): 77-85 PMID: 18360193 PubMed
  • Kempton MJ, Geddes JR, Ettinger U, Williams SCR, Grasby PM.  Meta-analysis, database and meta-regression of 98 structural imaging studies in bipolar disorder Archives of General Psychiatry  2008 65: 1017-1032 PMID: 18762588 PubMed
  • Geddes JR.  How to distinguish and manage bipolar disorder.  Pulse March 12th 2008
  • Nataragan R, Geddes JR.  Ongoing pharmacotherapy maintains quality of life benefits in older adults with major depression Evidence-Based Mental Health 2008 11: 34-35 PMID: 18441132 PubMed
  • Barbui C, Cipriani A, Geddes JR. Antidepressants and suicide symptoms: compelling new insights from the FDA’s analysis of individual patient level data.  Evidence-Based Mental Health 2008 11: 34-35 PMID: 18441126 PubMed
  • Cipriani A, Furukawa TA,  Geddes JR, Malvini L, Signoretti A, McGuire H,Churchill R, Nakagawa A, Barbui C. Does randomised evidence support sertraline as first-line antidepressant for adults with acute major depression? A systematic review and meta-analysis.  J Clin Psychiatry 2008 69: 1732-1742 PMID: 19026250 PubMed
  • Holmes EA, Geddes JR, Colom F & Goodwin GM.  Mental imagery as an emotional
    amplifier: Application to bipolar disorder. Behaviour Research and Therapy. 2008 46: 1251- 1258 PMID: 18990364 PubMed
  • Fazel S, Khosla V, Doll H, Geddes JR.  The prevalence of mental disorders among the
    homeless in Western countries: systematic review and meta-regression analysis.  PLoS
    Medicine 2008 5(12): 1670-1681 PMID: 2592351 PubMed fulltext
  • Geddes JR, Calabrese J, Goodwin GM.  Lamotrigine for treatment of bipolar depression: an independent meta-analysis and meta-regression of individual patient data from 5 randomized trials British Journal of Psychiatry  2009 194: 4-9 PMID: 19118318 PubMed
  • Geddes JR.  Clinical trial design: horses for courses.  World Psychiatry 2009 8(1): 28-29 PMID: 2652895 PubMed
  • Andrea Cipriani, Toshiaki A Furukawa, Georgia Salanti, John R Geddes, Julian PT Higgins, Rachel Churchill, Norio Watanabe, Atsuo Nakagawa, Ichiro M Omori, Hugh McGuire, Michele Tansella and Corrado Barbui.  Comparative efficacy and acceptability of 12 new generation antidepressants: A multiple treatments meta-analysis and database.  Lancet 2009 373(9665) PMID: 19185342 PubMed
  • S Beynon, K Soares-Weiser, N Woolacott, S Duffy and J R Geddes.  Pharmacological
    interventions for the prevention of relapse in bipolar disorder: a systematic review of
    controlled trials. J Psychopharmacol  2009 23(5): 574-591 (first published July 17 2008) PMID: 18635701 PubMed
  • Cipriani A, Rendell JR, Geddes JR.  Olanzapine in the long-term treatment of bipolar disorder.  A systematic review and meta-analysis.  J Psychopharmacol October 14 2009 doi:10.1177/0269881109106900 PMID: 19828571 PubMed
  • Cipriani A, Geddes JR.  What is a randomised controlled trial?  Epidemiologia e Psichiatrica 2009 Sociale 18( 3): 191-194 PMID: 20034195 PubMed
  • Fazel S, Geddes JR.  Schizophrenia and Violence: Systematic Review and Meta-Analysis.  PLoS Medicine 2009 6(8): e1000120 PMID: 19668362 PubMed
  • Stefanopoulou E, Manoharan A, Landau S, Geddes JR, Goodwin GM, Frangou S.  Cognitive functioning in patients with affective disorders and schizophrenia: A meta-analysis.  International Review of Psychiatry 200921(4): 336-356 PMID: 20374148 PubMed
  • Miklowitz D J, Alatiq Y, Goodwin G M, Geddes J R, Fennell M V F, Dimidjian S, Hauser M & Williams J M.G.  A pilot study of mindfulness-based cognitive therapy for bipolar  disorder. International Journal of Cognitive Therapy 2009 2(4): 373-382 External Link
  • Geddes JR,  Barbui C, Cipriani A.  Risk of suicidal behaviour in adults taking antidepressants.  British Medical Journal  2009 339:b3066 PMID: 19671934 PubMed
  • Geddes JR.  Evidence-Based Neurobehavioral Electrophysiology.  Clinical EEG and Neuroscience  2009 40(2): V-V PMID: 19534298 PubMed
  • Geddes JR, Carney S.  Evidence-Based Medicine and Neurophysiology.  Clinical EEG and Neuroscience 2009 40(2):59-62 PMID: 19534299 PubMed
  • Geddes J.  BALANCE: Initial results and methodological aspects of trails of maintenance treatments.  Bipolar Disorders 2009 11: 6
  • Ceron-Litvoc D, Soares BG, Geddes J,Litvoc J, De Lima MS.  Comparison of
    Carbamazepine and Lithium in treatment of Bipolar Disorder: A systematic review of
    randomized controlled trials.  Human Psychopharmacology: Clinical and Experimental. 2009 24: 19-28 PMID: 19053079 PubMed
  • Geddes JR, Goodwin GM, Rendell J, Azorin JM, Ostacher MJ, Morriss R, Alder N,
    Juszczak E for the BALANCE investigators and collaborators.  Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial.  Lancet  2010 375: 385-395 PMID: 20092882 PubMed
  • Cipriani A, Geddes JR.  What is a run-in phase?  Epidemiologia e Psichiatrica Sociale 2010 19(1): 21-22 PMID: 20486419 PubMed
  • Lloyd J, Doll H, Hawton K, Dutton WH, Geddes JR, Goodwin GM, Rogers RD.  Internet gamblers: a latent class analysis of their behaviours and health experiences.  Journal of Gambling Studies (ePub ahead of print) PMID: 20422442 PubMed
  • Joanne Lloyd, Helen Doll, Keith Hawton, William H Dutton, John R Geddes, Guy M Goodwin, and Robert D Rogers.  How psychological symptoms relate to different motivations for gambling: an online study of Internet gamblers.  Biological Psychiatry (in press) PMID: 20655512 PubMed
  • Kivimäki M, Jokela M, Hamer M, Geddes J, Ebmeier K, Kumari M, Davey Smith G, Singh-Manoux A, Hingorani A, Batty GD.  Examining Overweight and Obesity as Risk Factors for Common Mental Disorder Using FTO Genotype-Instrumented Analysis: the Whitehall II Study, 1985-2004.  American Journal of Epidemiology 2010 (in press)
  • Bopp JM, Miklowitz DJ, Goodwin GM, Stevens W, Rendell JM, Geddes JR.  The longitudinal course of bipolar disorder as revealed through weekly text messaging: a feasibility study. Bipolar Disord 2010 12: 327–334 PMID: 2921773 PubMed
  • Miklowitz DJ, Alatiq Y, Geddes JR, Goodwin GM, Williams JMG.  Thought Suppression in Patients with Bipolar Disorder, J Abnorm. Psychol. 2010 119 (2): 355-365 PMID: 2869476 PubMed
  • R Whale, T Terao, P Cowen, N Freemantle and J Geddes.  Pindolol augmentation of
    serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review.J Psychopharmacol 2010 24(4): 513-520 (first published 2 October 2008) PMID: 18832428 PubMed
  • Mika Kivimäki, Mark Hamer, G. David Batty, John R. Geddes, Adam G. Tabak, Jaana Pentti, Marianna Virtanen, Jussi Vahtera.  Antidepressant Medication Use, Weight Gain and Risk of Type 2 Diabetes Mellitus: A Population-based Study.  Diabetes Care 2010 in press.

Cochrane Reviews & Protocols

  • Burgess S, Geddes J, Hawton K, Townsend E, Jamison K, Goodwin G. Lithium for maintenance treatment of mood disorders. The Cochrane Database of Systematic Reviews Issue 2001, Art. No.: CD003013 Wiley
  • Macritchie K.A.N., Geddes J.R., Scott J, Haslam D.R.S., Goodwin G.M. Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. The Cochrane Database of Systematic Reviews 2001, Art. No.: CD003196 Wiley
  • Taylor MJ, Carney S, Geddes J, Goodwin G. Folate for depressive disorders. The Cochrane Database of Systematic Reviews 2003, Art. No.: CD003390 Wiley
  • Rendell JM, Gijsman HJ, Keck P, Goodwin GM, Geddes JR. Olanzapine alone or in combination for acute mania. The Cochrane Database of Systematic Reviews 2003, Art. No.: CD004040 Wiley
  • Macritchie K, Geddes JR, Scott J, Haslam D, de Lima M, Goodwin G. Valproate for acute affective episodes in bipolar disorder. The Cochrane Database of Systematic Reviews 2003, Art. No.: CD004052 Wiley
  • Taylor MJ, Wilder H, Bhagwagar Z Geddes J Inositol for depressive disorder. The Cochrane Database of Systematic Reviews 2004, Art. No.: CD004049 Wiley
  • Cipriani A, Brambilla P, Furukawa T, Geddes J, Gregis M, Hotopf M, Malvini L, Barbui C. Fluoxetine versus other types of pharmacotherapy for depression. The Cochrane Database of Systematic Reviews 2005, Art. No.: CD004185.pub2 Wiley
  • Wijkstra J, Lijmer J, Balk F, Geddes J, Nolen WA. Pharmacological treatment for psychotic depression. The Cochrane Database of Systematic Reviews 2005, Art. No.: CD004044.pub2 Wiley
  • Cipriani A, Rendell JM, Geddes JR.  Haloperidol alone or in combination for acute mania.  Cochrane Database of Systematic Reviews 2006 CD 004362  Art. No.: CD004362.pub2. Wiley
  • Cipriani A, Smith K, Burgess S, Carney S, Goodwin G, Geddes JR.  Lithium versus antidepressants in the maintenance treatment of depressive disorder.  Cochrane Database Syst Rev 2006 CD 003492 Art. No.: CD003492.pub2. Wiley
  • Rendell JM, Gijsman HJ, Bauer MS, Goodwin GM, Geddes JR.  Risperidone alone or in combination for acute mania.  Cochrane Database Syst Rev Issue 1 CD004043.pub2 2006 Art. No.: CD004043.pub2. Wiley
  • Rendell JM, Geddes JR.  Risperidone in long-term treatment for bipolar disorder.  Cochrane Database Syst Rev 2006 Issue 4 CD 004999 Art. No.: CD004999.pub2. Wiley
  • Barbui C, Hotopf M, Freemantle N, Boynton J, Churchill R, Eccles MP, Geddes JR, Hardy R, Lewis G, Mason JM. Selective serotonin reuptake inhibitors (SSRIs) versus other antidepressants for depression. The Cochrane Database of Systematic Reviews 2006, Art. No.: CD001851 Wiley
  • Young AH, Geddes JR, MacRitchie K, Rao SNK, Vasudev A.  Tiagabine in the maintenance treatment of bipolar disorders.  Cochrane Database Syst Rev 2006 CD005173 Art. No.: CD005173.pub2. Wiley
  • Young AH, Geddes JR, MacRitchie K, Rao SNK, Watson S, Vasudev A.  Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability.  Cochrane Database Syst Rev 2006 CD004694 Art. No.: CD004694.pub2. Wiley
  • Rendell JM, Merritt RK, Geddes JR.  Incentives and disincentives to participation by clinicians in randomised controlled trials.  Cochrane Database Syst Rev 2007 CD MR000021 Art. No.: MR000021.pub3. Wiley
  • Vasudev  A, Macritchie K, Watson S, Geddes JR, Young AH.  Oxcarbazepine in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev 2008 CD005171 Art. No.: CD005171.pub2. Wiley
  • Cipriani A, Rendell JR, Geddes JR.  Olanzapine in the long-term treatment for bipolar disorder. Cochrane Database Syst Rev 2009 CD004367 Art. No.: CD004367.pub2. Wiley


 
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